Gut Check

Month: February 2021

Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

Our results indicate that overweight or obesity is a favorable prognostic factor independent of gut diversity. In addition, our results demonstrate that patients with better clinical survival exhibit higher diversity as well as a distinct gut microbiome composition. At last, the association between gut diversity and local immune signatures suggests that patients with high gut diversity develop increased infiltration of activated CD4+ T-cell subsets and highlights helper CD4+ T cells as potential mediators of antitumor immunity upon CRT treatment.

Diabetes and the Gut Microbiome

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn One of the ways your diet affects your health status is by modulating the composition of your gut microbiota. It has been found that normal gut microbiota affects the development of the immune system, nutrient absorption, tissue generation and …

Diabetes and the Gut Microbiome Read More »

Bacteroidetes and Firmicutes: What’s the Deal?

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn The gut microbiome is the collection of bacteria, archaea, and eukarya that reside in the human gastrointestinal tract. Due to its roles in a broad range of physiological functions, the gut microbiome is now thought of as an organ …

Bacteroidetes and Firmicutes: What’s the Deal? Read More »

Let Us Get to Know Lactobacillus

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn Just like you and me, bacteria have families too. One such family is the Lactobacillaceae, a group of bacteria characterized by their lactic acid-producing capabilities. Family members generally share the same characteristics. For example, Lactobacilliceae have the ability to …

Let Us Get to Know Lactobacillus Read More »

How Does the Chinese New Year Diet Change our Gut Microbiome?

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn Chinese New Year is a festival celebrated by many worldwide. Various traditions like having reunion dinner with your extended family, consuming various festive treats, and beautifying your house with a variety of streamers and banners are all common during …

How Does the Chinese New Year Diet Change our Gut Microbiome? Read More »

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

We observed clinical responses in three patients, including two partial responses and one complete response. Notably, treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment. In conclusion, FMT from CR donors and re-induction of anti-PD-1 therapy in refractory metastatic melanoma patients was safe and feasible. In some patients, this treatment increased the intra-tumoral immune activity, which was translated into objective clinical responses. These findings support the concept of overcoming resistance to immunotherapy by modulating the gut microbiota.

Impact of microbial metabolites on microbiota-gut-brain axis in inflammatory bowel disease

This review highlights the more recent evidence suggesting that alterations of the microbiota–gut–brain bidirectional communication axis may concur to IBD pathogenesis and sustain the development of both local and CNS symptoms. The participation of the main microbial-derived metabolites, also defined as “postbiotics”, such as bile acids, short-chain fatty acids, and tryptophan metabolites in the development of IBD-associated gut and brain dysfunction will be discussed. Changes in gut-brain axis communication may contribute to the development of chronic visceral pain and hypersensitivity, representing the most common cause of disability and impaired quality of life in IBD.

Does Geography Affect the Gut Microbiome?

Share on facebook Facebook Share on google Google+ Share on twitter Twitter Share on linkedin LinkedIn Populations that live in different regions of the world have varying taxonomic compositions. Geographical location has an impact on the microbial populations due to prominent differences in diet across geographic regions. The abundance of a certain enterotype varies from …

Does Geography Affect the Gut Microbiome? Read More »